Back to HomeEvidence-Based Approach

The Science Behind AgeWell

Every claim we make is grounded in peer-reviewed research. We reference over 700 clinical studies on creatine monohydrate to ensure our product and content meet the highest scientific standards.

Our Research Standards

At AgeWell, we believe transparency starts with rigorous science. Every piece of content we publish is reviewed against the latest peer-reviewed literature on creatine monohydrate. We do not make claims that are not supported by clinical evidence, and we clearly cite the studies that inform our formulation and educational materials.

Our research review process draws from leading journals in sports science, nutrition, aging, and neuroscience, including:

Frontiers in Aging Neuroscience
Nutrients
Journal of the International Society of Sports Nutrition
Aging Cell
Bone Reports
Nature Medicine

Key Studies We Reference

The following landmark studies form the scientific foundation of AgeWell. Each has been published in a peer-reviewed journal and contributes to our understanding of creatine's role in healthy aging.

2003Proceedings of the Royal Society B

Oral creatine monohydrate supplementation improves brain performance

Rae C, Digney AL, McEwan SR, Bates TC

Demonstrated that creatine supplementation significantly improved working memory and processing speed in healthy adults, establishing creatine as a cognitive enhancer beyond athletic performance.

2015Medicine & Science in Sports & Exercise

Effects of creatine and resistance training on bone health in postmenopausal women

Chilibeck PD, Candow DG, Landeryou T, Kaviani M, Paus-Jenssen L

Found that creatine combined with resistance training improved bone mineral density in postmenopausal women, suggesting creatine as a safe adjunct for bone health in aging populations.

2017Journal of the International Society of Sports Nutrition

International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation

Kreider RB, Kalman DS, Antonio J, et al.

The ISSN concluded that creatine monohydrate is the most effective ergogenic nutritional supplement for increasing high-intensity exercise capacity and lean body mass, with no scientific evidence of adverse effects in healthy individuals.

2018Experimental Gerontology

Effects of creatine supplementation on cognitive function of healthy individuals: a systematic review

Avgerinos KI, Spyrou N, Bougioukas KI, Kapogiannis D

Systematic review found that creatine supplementation improves short-term memory and reasoning in healthy individuals, with the most pronounced benefits in aging adults and those under cognitive stress.

2019Nutrients

Meta-analysis examining the importance of creatine ingestion strategies on lean tissue mass and strength in older adults

Forbes SC, Candow DG, Ostojic SM, Roberts MD, Chilibeck PD

Meta-analysis confirmed that creatine supplementation combined with resistance training leads to significantly greater increases in lean tissue mass and upper body strength in older adults compared to resistance training alone.

2021Bone Reports

Effectiveness of creatine supplementation on aging muscle and bone

Candow DG, Forbes SC, Chilibeck PD, Cornish SM, Antonio J, Kreider RB

Comprehensive review established that creatine supplementation, combined with resistance training, has potential benefits for aging muscle and bone biology, supporting its use as a cost-effective intervention for sarcopenia and osteoporosis prevention.

Our Commitment to Transparency

Third-Party Tested

Every batch of AgeWell Creatine is independently tested by a third-party laboratory for purity, potency, and contaminants. We verify that what is on the label is exactly what is in the jar.

No Fillers or Additives

AgeWell contains one ingredient: pure creatine monohydrate. No fillers, no artificial colors, no unnecessary additives. Just the compound backed by decades of research.

FDA GRAS Status

Creatine monohydrate holds FDA GRAS (Generally Recognized as Safe) status. It is one of the most well-studied dietary supplements in history, with over 30 years of safety data.

Pure Creatine Monohydrate

We use creatine monohydrate because it is the form with the most scientific support. Other forms have not demonstrated superior bioavailability or effectiveness in clinical research.

About the AgeWell Research Team

AgeWell Research Team

Evidence-based creatine research for aging populations

The AgeWell Research Team is dedicated to reviewing and synthesizing the scientific literature on creatine monohydrate as it relates to healthy aging. We specialize in translating complex clinical research into accessible, actionable information for adults over 40 who want to make evidence-based decisions about supplementation.

Our team monitors ongoing research from peer-reviewed journals in sports nutrition, gerontology, neuroscience, and bone health. We evaluate studies for methodological rigor, sample size, and relevance to aging populations before incorporating their findings into our content.

We are committed to presenting research honestly, including its limitations. Where the evidence is strong, we say so. Where more research is needed, we are transparent about that as well. Our goal is to empower our customers with the knowledge they need to age well.

700+ Studies ReviewedPeer-Reviewed Sources OnlyFocused on Aging PopulationsRegularly Updated Content

Ready to try AgeWell Creatine?

Pure creatine monohydrate. Third-party tested. No fillers. Free US shipping. Backed by the research you just read.

Shop Now — $25